Melatonin in powder form


Melatonin is a hormone naturally produced by the body that plays an important role in the body’s synchronization to light-dark cycles, and the regulation of circadian rhythm. Melatonin supplements have been clinically studied in adults and children and have been found to work with the body's natural cycle to safely and gently promote sleep, and help support a regular sleep cycle.1,2*

Zarbee's Sleep Support

Watch our founder, Dr. Zak Zarbock, explain his philosophy about sleep.


Properties and mechanism of action

Naturally produced melatonin is a hormone, just like insulin or vitamin D—which means it is a signaling molecule released by the endocrine system. Once secreted by the pineal gland, melatonin binds to hormonal receptors throughout the body, including a part of the brain that regulates the body’s internal clock.3
Exogenous melatonin does not diminish the body’s ability to produce melatonin naturally.4 With a half-life of 35 to 50 minutes, exogenous melatonin reaches peak plasma concentrations after 60 minutes of administration, and 90% of it is cleared in a single passage through the liver.5,6 A small amount is excreted in urine, and a small amount is found in saliva.6

Scientific support

Recent short- and long-term safety evaluations have demonstrated melatonin’s favorable safety profile for children.7-11 Multiple studies have also shown that melatonin improves sleep onset latency and sleep duration among children and adults.12-18*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.